| Identification | Back Directory | [Name]
Triethylene Glycol 2-Bromoethyl Methyl Ether | [CAS]
110429-45-3 | [Synonyms]
mPEG4-Br
m-PEG4-bromo
m-PEG4-bromide
Br-(CH2CH2O)4-Me
Bromo-PEG4-methoxy
Methyl-PEG4-bromide
1-Bromo-3,6,9,12-tetraoxatridecane
13-Bromo-2,5,8,11-tetraoxatridecane
2,5,8,11-Tetraoxatridecane, 13-bromo-
Triethylene Glycol 2-Bromoethyl Methyl Ether
2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide
2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide
1-Bromo-3,6,9,12-tetraoxatridecane | [Molecular Formula]
C9H19BrO4 | [MDL Number]
MFCD12545963 | [MOL File]
110429-45-3.mol | [Molecular Weight]
271.149 |
| Chemical Properties | Back Directory | [Boiling point ]
296.3±25.0 °C(Predicted) | [density ]
1.256±0.06 g/cm3(Predicted) | [refractive index ]
1.4620 to 1.4660 | [storage temp. ]
2-8°C | [form ]
clear liquid | [color ]
White to Yellow to Green | [CAS DataBase Reference]
110429-45-3 |
| Hazard Information | Back Directory | [Description]
m-PEG4-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media. | [Biological Activity]
Triethylene Glycol 2-Bromoethyl Methyl Ether is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs) of trastuzumab (HY-P9907). It was placed distal to the monomethyl auristatin E (MMAE) payload to generate ADCs with altered hydrophilicity, antigen binding and in vitro potency. Tetraethylene glycol monotosylate can also be used as a linker of PROTAC, which can be used for the synthesis of PROTAC. | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
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| Company Name: |
Gold
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J & K SCIENTIFIC LTD.
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https://www.jkchemical.com |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
| Company Name: |
T&W GROUP
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021-61551611 13296011611 |
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www.trustwe.com/ |
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Tags:110429-45-3
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