| Identification | Back Directory | [Name]
Fatostatin A | [CAS]
125256-00-0 | [Synonyms]
125B11
Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-
4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole | [Molecular Formula]
C18H18N2S | [MDL Number]
MFCD02376000 | [MOL File]
125256-00-0.mol | [Molecular Weight]
294.41 |
| Chemical Properties | Back Directory | [Boiling point ]
474.3±55.0 °C(Predicted) | [density ]
1.125±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Soluble in DMSO (up to 25 mg/ml). | [form ]
solid | [pka]
3.46±0.10(Predicted) | [color ]
Yellow | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice.1?Inhibits high glucose-induced TGF-β in mesangial cells.2?Cell permeable. | [Uses]
Fatostatin A is Cell permeable inhibitor of SREBP activation. | [Definition]
ChEBI: 4-(4-methylphenyl)-2-(2-propyl-4-pyridinyl)thiazole is a member of thiazoles. | [References]
1) Kamisuki et al. (2009), A small molecule that blocks fat synthesis by inhibiting the activation of SREBP; Chem. Biol., 16 882
2) Uttarwar et al. (2012), SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells; Am. J. Physiol. Renal Physiol., 302 F329 |
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| Company Name: |
Mashilabs (Shanghai) Co.,Ltd.
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| Tel: |
021-00000000 19916721580 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList16374/0.htm |
| Company Name: |
Twochem Co.Ltd
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| Tel: |
021-58111628 15800915896 |
| Website: |
http://www.twochem.com |
| Company Name: |
BePharm Ltd
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| Tel: |
400-685-9117 |
| Website: |
www.bepharm.com |
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