125256-00-0

中文名称 FATOSTATIN A

英文名称 Fatostatin A

CAS 125256-00-0

分子式 C18H18N2S

分子量 294.41

MOL 文件 125256-00-0.mol

更新日期 2024/04/11 10:57:32

125256-00-0 结构式

基本信息物理化学性质安全数据 FATOSTATIN A价格(试剂级) 常见问题列表

基本信息

中文别名

脂肪抑制素

英文别名

125B11
Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-
4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole

物理化学性质

沸点474.3±55.0 °C(Predicted)

密度1.125±0.06 g/cm3(Predicted)

储存条件Inert atmosphere,2-8°C

溶解度溶于 DMSO（高达 25 mg/ml）。

酸度系数(pKa)3.46±0.10(Predicted)

形态固体

颜色黄色

稳定性DMSO中的溶液可在-20°下稳定储存3个月。

安全数据

危险性符号(GHS)

GHS06

警示词危险

危险性描述H413-H301

防范说明P264-P270-P301+P310-P321-P330-P405-P501

FATOSTATIN A价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/01/16	S9785	FATOSTATIN A Fatostatin	125256-00-0	5mg	795.2元
2024/01/16	S9785	Fatostatin	125256-00-0	10mM (1mL in DMSO)	958.23元
2024/01/16	S9785	FATOSTATIN A Fatostatin	125256-00-0	25mg	2375.39元

常见问题列表

生物活性

Fatostatin (125B11) 是一种diarylthiazole的衍生物，是 Sterol regulatory element binding proteins (SREBPs) 活化的特异性抑制剂。Fatostatin 可结合SCAP (SREBP cleavage-activating protein)，并抑制SREBP的ER-Golgi易位。Fatostatin 可抑制癌细胞生长并增强癌细胞的凋亡。

靶点

Target	Value
SREBP ()

体外研究

Fatostatin (125B11) (0.1-1 μM; 3 days) inhibits the androgen-independent prostate cancer cell proliferation (IC ₅₀ =0.1 μM) in an independent of the known IGF1-signaling pathway. Fatostatin inhibits insulin-induced adipogenesis of 3T3-L1 cells.
Fatostatin directly binds SCAP and blocks its ER-to-Golgi transport with IC ₅₀ of 2.5 and 10 μM in mammalian cells.

Cell Proliferation Assay

Cell Line:	DU-145 cells
Concentration:	0.1, 1 μM
Incubation Time:	3 days
Result:	Impaired the IGF1-induced growth at an IC ₅₀ of 0.1 μM.

体内研究

Fatostatin (125B11) (30 mg/kg; 150 μL; i.p. injection; daily for 28 days) reduces adiposity, ameliorated fatty liver by reducing triglyceride (TG) storage, and lowered hyperglycemia in ob/ob mice.

Animal Model:	Four-to-five-week-old homozygous male obese ( ob/ob ) mice (C57BL/6J)
Dosage:	30 mg/kg; 150 μL
Administration:	i.p. injection; daily for 28 days
Result:	Blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.