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1254032-66-0

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1254032-66-0 Structure

1254032-66-0 Structure
IdentificationBack Directory
[Name]

Besifovir
[CAS]

1254032-66-0
[Synonyms]

AR-11324
Netarsudil，Besifovir
Netarsudil Impurity 8
(S)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate
Benzoic acid, 2,4-dimethyl-, [4-[(1S)-1-(aminomethyl)-2-(6-isoquinolinylamino)-2-oxoethyl]phenyl]methyl ester
[Molecular Formula]

C28H27N3O3
[MDL Number]

MFCD28502136
[MOL File]

1254032-66-0.mol
[Molecular Weight]

453.53
Chemical PropertiesBack Directory
[Boiling point ]

711.9±60.0 °C(Predicted)
[density ]

1.250±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

12.84±0.43(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

Netarsudil is a Rho kinase (ROCK) and norepinephrine transporter (NET) inhibitor. Netarsudil increases outflow facility in human eyes through multiple mechanisms[1].
[References]

[1] Ren R, et al. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6197-6209. DOI:10.1167/iovs.16-20189
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