| Identification | Back Directory | [Name]
AZD1979 | [CAS]
1254035-84-1 | [Synonyms]
AZD1979
AZD-1979
(AZD1979
Methanone, [5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl][3-[4-(2-oxa-6-azaspiro[3.3]hept-6-ylmethyl)phenoxy]-1-azetidinyl]-
[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[3-[4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)-phenoxy]azetidin-1-yl]methanone | [Molecular Formula]
C25H26N4O5 | [MDL Number]
MFCD30471075 | [MOL File]
1254035-84-1.mol | [Molecular Weight]
462.5 |
| Chemical Properties | Back Directory | [Boiling point ]
636.6±65.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
8.05±0.20(Predicted) | [color ]
Off-white to light yellow | [InChI]
InChI=1S/C25H26N4O5/c1-31-19-8-4-18(5-9-19)22-26-27-23(34-22)24(30)29-11-21(12-29)33-20-6-2-17(3-7-20)10-28-13-25(14-28)15-32-16-25/h2-9,21H,10-16H2,1H3 | [InChIKey]
BKKPIQPFRAPEAY-UHFFFAOYSA-N | [SMILES]
C(C1=NN=C(C2=CC=C(OC)C=C2)O1)(N1CC(OC2=CC=C(CN3CC4(COC4)C3)C=C2)C1)=O |
| Hazard Information | Back Directory | [Uses]
AZD1979 is a Melanin-concentrating hormone receptor 1 (MCHr1) antagonist with an IC50 of ~12 nM. | [Definition]
ChEBI: AZD1979 is a carboxamide resulting from the formal condensation of the carboxy group of 5-(p-methoxyphenyl)-1,3,4-oxadiazole-2-carboxylic acid with the amino group of 3-phenoxyazetidine and in which the phenoxy group has been substituted at the para- position by a 2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl group. It is a melanin concentrating hormone receptor 1 (MCHr1) antagonist. It has a role as a melanin-concentrating hormone receptor antagonist. It is an azaspiro compound, an oxaspiro compound, an oxadiazole, a N-acylazetidine, a member of oxetanes, an aromatic ether and a carboxamide. It is a conjugate base of an AZD1979(1+). | [in vivo]
In DIO mice, initial AZD1979-mediate body weight loss is driven by decreasing food intake, but an additional component of preserving energy expenditure is apparent in pair-feeding and indirect calorimetry studies. AZD1979 also dose-dependently reduces body weight in dogs[1]. | [References]
[1] Ploj K, et al. Effects of a novel potent melanin-concentrating hormone receptor 1 antagonist, AZD1979, on body weight homeostasis in mice and dogs. Br J Pharmacol. 2016 Sep;173(18):2739-51. DOI:10.1111/bph.13548 |
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