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1254473-64-7

1254473-64-7 Structure

1254473-64-7 Structure
IdentificationBack Directory
[Name]

LY 2874455
[CAS]

1254473-64-7
[Synonyms]

LY 2874455
LY2874455/LY-2874455
(R,E)-2-(4-(2-(5-(1-(3,5-Dichloropyridin-4-yl)-ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)
(E)-2-(4-(2-(5-(1-(3,5-DICHLOROPYRIDIN-4-YL)ETHOXY)-1H-INDAZOL-3-YL)VINYL)-1H-PYRAZOL-1-YL)ETHANOL
(R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol
4-[(1E)-2-[5-[(1R)-1-(3,5-Dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-1H-pyrazole-1-ethanol
(R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethan-1-ol
4-[(1E)-2-[5-[(1R)-1-(3,5-Dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-1H-pyrazole-1-ethanol LY2874455
[Molecular Formula]

C21H19Cl2N5O2
[MDL Number]

MFCD22124884
[MOL File]

1254473-64-7.mol
[Molecular Weight]

444.314
Chemical PropertiesBack Directory
[Boiling point ]

672.6±55.0 °C(Predicted)
[density ]

1.44
[pka]

12.93±0.40(Predicted)
[CAS DataBase Reference]

1254473-64-7
Questions And AnswerBack Directory
[Description]

LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM. Phase 1.
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