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1258296-60-4

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1258296-60-4 Structure

1258296-60-4 Structure
IdentificationBack Directory
[Name]

RO495
[CAS]

1258296-60-4
[Synonyms]

RO495
CS-2667
RO495/RO-495
RO495 (TYK Tool 1)
Benzamide, N-[2-[(2-amino-6-methyl-4-pyrimidinyl)amino]-4-pyridinyl]-2,6-dichloro-
[Molecular Formula]

C17H14Cl2N6O
[MDL Number]

MFCD21364479
[MOL File]

1258296-60-4.mol
[Molecular Weight]

389.24
Chemical PropertiesBack Directory
[density ]

1.517±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 78 mg/mL (200.39 mM);Ethanol: Insoluble
[form ]

Solid
[pka]

10.48±0.70(Predicted)
[color ]

Light yellow to yellow
[Water Solubility ]

Water: Insoluble
Hazard InformationBack Directory
[Uses]

RO495 is a potent inhibitor of non-receptor tyrosine-protein kinase 2 (TYK2 kinase)[1].
[References]

[1] Tobie D. Lee, et al. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology November 2019, 96 (5) 629-640. DOI:10.1124/mol.119.115964
Spectrum DetailBack Directory
[Spectrum Detail]

RO495(1258296-60-4)1HNMR
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