| Identification | Back Directory | [Name]
3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide | [CAS]
199666-03-0 | [Synonyms]
CS-1828
R061-8048
Ro 61-8048, >=98%
Ro 61-8048 >=98% (HPLC)
KMO Inhibitor I, Ro 61-8048
KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem
3,4-Dimethoxy-N-4-(3-nitro-phenyl)-thiazol-2-yl-benzenesulfomide
3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide
3,4-diMethoxy-N-(4-(3-nitrophenyl)thiazol-2-yl)benzenesulfonaMide
Benzenesulfonamide, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-
3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
RO61-80483,4-dimethoxy-N-(4-(3-nitrophenyl)thiazol-2-yl)Benzenesulfonamide
3,4-dimethoxy 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
NMDA,Ro 61 8048,inhibit,Ro 61-8048,dystonia,Inhibitor,hydroxylase,Ro 618048,kynurenine
3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide RO61-8048
RO 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide | [Molecular Formula]
C17H15N3O6S2 | [MDL Number]
MFCD11040807 | [MOL File]
199666-03-0.mol | [Molecular Weight]
421.45 |
| Chemical Properties | Back Directory | [Melting point ]
185℃ | [Boiling point ]
627.4±65.0 °C(Predicted) | [density ]
1.471±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥15mg/mL | [form ]
Yellow solid | [pka]
6.29±0.10(Predicted) | [color ]
faint yellow to yellow | [InChI]
1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19) | [InChIKey]
NDPBMCKQJOZAQX-UHFFFAOYSA-N | [SMILES]
COc1ccc(cc1OC)S(=O)(=O)Nc2nc(cs2)-c3cccc(c3)[N+]([O-])=O |
| Hazard Information | Back Directory | [Uses]
Ro 61-8048 is a potent and competitive kynurenine 3-monooxygenase (KMO) inhibitor. | [Definition]
ChEBI: Ro 61-8048 is a C-nitro compound. | [Biological Activity]
Potent and competitive kynurenine 3-hydroxylase inhibitor (K i = 4.8 nM, IC 50 = 37 nM). Increases kynurenic acid levels to concentrations that antagonize the glycine site of NMDA receptors. Brain penetrant and exhibits antidystonic, anticonvulsant and neuroprotective activities. | [Biochem/physiol Actions]
Ro 61-8048 is an inhibitor of kynurenine 3-monooxygenase (KMO) that increases kynurenic acid levels and reduces extracellular glutamate in the brain. | [storage]
+4°C |
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