| Identification | Back Directory | [Name]
VU0155041 sodium salt | [CAS]
1259372-69-4 | [Synonyms]
VU0155041 sodium salt
cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylicacidsodiumsalt | [Molecular Formula]
C14H14Cl2NNaO3 | [MOL File]
1259372-69-4.mol | [Molecular Weight]
338.162 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at RT | [solubility ]
DMSO: 1 mg/ml; PBS (pH 7.2): 2 mg/ml | [form ]
Powder | [Water Solubility ]
Soluble to 25 mM in water |
| Hazard Information | Back Directory | [Description]
VU0155041 is a positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4) with an EC50 value of 2.5 μM for glutamate response in a thallium flux assay. It is selective for mGluR4, exhibiting no effect on radioligand binding at 67 G protein-coupled receptors, ion channels, and transporters, and lacking antagonist activity at NMDA receptors in striatal medium spiny neurons at a concentration of 10 μM. In vivo, VU0155041 decreases catalepsy induced by haloperidol and reverses askinesias induced by reserpine in rat models of Parkinson’s disease. Chronic treatment with VU0155041 restores social behavior in the Oprm-/- mouse model of autism. It also increases the percentage of time spent in the open arms of the elevated plus maze, a measure of decreased anxiety, in mice. | [Uses]
VU 0155041 Sodium Salt is a positive allosteric modulator of group III mGlu4 receptor that provides functional neuprotection in 6-hydroxydopamine rat models with parkinson’s disease. | [in vivo]
VU0155041 (31 nmol, 93 nmol; i.c.v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats[1].
VU0155041 (93 nmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480) -induced akinesia in rats[1]. | Animal Model: | Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g)[1] | | Dosage: | 31, 93 nmol | | Administration: | I.c.v. injection after the the 1.5 mg/kg of haloperidol treatment 2 h | | Result: | Decreased the cataleptic effects of haloperidol, and the effects still presented 30 min after infusion. |
| [IC 50]
mGluR4: 693 nM (EC50) | [storage]
Desiccate at RT |
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