| Identification | Back Directory | [Name]
28-deoxonimbolide | [CAS]
126005-94-5 | [Synonyms]
28-deoxonimbolide
2H,5H-Cyclopenta[b]furo[2',3',4':4,5]naphtho[2,3-d]furan-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-5-oxo-, methyl ester, (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cS)- | [Molecular Formula]
C27H32O6 | [MDL Number]
MFCD26406046 | [MOL File]
126005-94-5.mol | [Molecular Weight]
452.54 |
| Hazard Information | Back Directory | [Uses]
28-Deoxonimbolide is a nimbin (HY-N3187) type limonoid, that can be isolated from Azadirachta indica seed extracts. 28-Deoxonimbolide shows anticancer activity. 28-Deoxonimbolide induces apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways[1]. | [Definition]
ChEBI: A limonoid isolated from Azadirachta indica. | [target]
Caspase | [IC 50]
Caspase-8; Caspase-9; Caspase-3 | [References]
[1] Kikuchi T, et al. Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem). J Nat Prod. 2011 Apr 25;74(4):866-70. DOI:10.1021/np100783k |
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