| Identification | More | [Name]
2,3-Difluoro-4-hydroxybenzonitrile | [CAS]
126162-38-7 | [Synonyms]
2,3-DIFLUORO-4-HYDROXYBENZONITRILE
4-CYANO-2,3-DIFLUOROPHENOL
BUTTPARK 13\03-07
Benzonitrile, 2,3-difluoro-4-hydroxy-(9CI) | [Molecular Formula]
C7H3F2NO | [MDL Number]
MFCD00269596 | [Molecular Weight]
155.1 | [MOL File]
126162-38-7.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
3439 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
2926907090 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless needles | [Synthesis]
a) 4-ethoxy-2,3-difluorobenzaldehyde
Add 125 ml, 0.2 mol of n-butyllithium hexane solution, 0.2 mol of 2,3-difluorophenyl, 0.2 mol of tetramethylethylenediamine to 400 ml of tetrahydrofuran solution at -78°C, stir the mixture at 70°C, keep it |
| Questions And Answer | Back Directory | [Application]
2,3-Difluoro-4-cyanophenol can be used as a pharmaceutical synthesis intermediate. It can be prepared by reacting 2,3-difluorophenyl with N-formaldehyde piperidine to prepare intermediate 4-ethoxy-2,3-difluorobenzaldehyde, further reacting it with hydroxylamine-O-sulfonic acid to prepare intermediate 4-ethoxy-2,3-difluorobenzyl nitrile, and then reacting it with aluminum chloride to obtain the final product. |
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