| Identification | Back Directory | [Name]
cerebrolysin | [CAS]
12656-61-0 | [Synonyms]
FPE 1070
cerebrolysin
CEREBROLYSIN CONCENTRATE | [EINECS(EC#)]
1592732-453-0 |
| Questions And Answer | Back Directory | [Uses]
cerebrolysin is a drug that can replenish qi and nourish yang, improve intelligence and calm the mind, nourish the kidneys and brain. It can be used for neurasthenia, fatigue and dizziness caused by cerebral arteriosclerosis, stroke, hemiplegia, cerebral hematoma after hypertensive cerebral hemorrhage, cerebral thrombosis, insomnia and dreaminess, memory loss and other symptoms. | [Pharmacological Study]
Cerebrolysin is a peptidergic drug produced from purified
porcine brain proteins, with postulated neurotrophic and
neuroprotective effects (Windisch et al., 1998; Rockenstein
et al., 2003; Plosker and Gauthier, 2009; Gauthier et al.,
2015). A small open-label trial in patients with AD and VaD
(Rainer et al., 1997) showed minimal improvement in cognitive
tests and clinical global impression. The main side
effects were nausea and vertigo. A Cochrane review (Chen et al., 2013) of six RCTs with a total of 597 participants
showed minimal MMSE and ADAS-cog improvements. |
| Hazard Information | Back Directory | [Indications]
Contraindications are hypersensitivity to the protein lysate or the excipients; epilepsy, especially grand mal convulsions (Cerebrolysin treatment may increase the frequency of seizures); severe or acute kidney failure; there is no available information on the safety of Cerebrolysin during pregnancy and lactation in humans, though animal studies found no toxic effects; some studies have shown that Cerebrolysin can be safely used in patients with acute hemorrhagic stroke. | [Side effects]
The side effects of Cerebrolysin are infrequent and usually mild and transient: agitation (aggressiveness, insomnia, rarely hallucinations), confusion, tremors, allergic reactions–very rare, in our expertise (fever, skin reactions, pruritus, local vascular reactions, headache, neck pain, limb pain, lower backache, dyspnea, chills, shock-like state), vertigo, headache, hypertension or hypotension, hyperventilation, hypertonia or hypotonia, fatigue, depression, apathy, flu-like symptoms, gastro–intestinal troubles (loss of appetite, dyspepsia, diarrhea, constipation, nausea, vomiting), rapid injection may cause heat sensation, sweatiness, dizziness, rarely palpitations or cardiac arrhythmias, injection site reactions (irritation, pruritus, burning sensation)[1].
| [References]
[1] G Onose. “Neuroprotective and consequent neurorehabilitative clinical outcomes, in patients treated with the pleiotropic drug cerebrolysin.” Journal of Medicine and Life 2 4 (2009): 350–60.
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| Company Name: |
AFINE CHEMICALS LIMITED
|
| Telephone: |
+86-571-85134551 +86-18958018566 |
| Website: |
www.afinechem.com/index.html |
| Company Name: |
Lotusland Life Sciences
|
| Telephone: |
+8615821988213 |
| Website: |
https://www.chemicalbook.com/manufacturer/shanghai-longyu-biotechnology-164/ |
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