| Identification | Back Directory | [Name]
CAY10678 | [CAS]
1268709-57-4 | [Synonyms]
CAY10678
CAY10678 Exclusive
N-Cyclopentyl-1-(1-isopropyl-5,6-dimethyl-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamide
N-Cyclopentyl-1-[5,6-dimethyl-1-(1-methylethyl)-1H-benzimidazol-2-yl]-4-piperidinecarboxamide
4-Piperidinecarboxamide, N-cyclopentyl-1-[5,6-dimethyl-1-(1-methylethyl)-1H-benzimidazol-2-yl]-
1-(1-isopropyl-5,6-dimethyl-1H- benzoimidazol-2-yl)-piperidine-4-carboxylic acid cyclopentylamide | [Molecular Formula]
C23H34N4O | [MOL File]
1268709-57-4.mol | [Molecular Weight]
382.54 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 15 mg/ml; DMSO: 5 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS (pH 7.2) (1:8): 0.1 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
N-Cyclopentyl-1-(1-isopropyl-5,6-dimethyl-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamide is a benzoimidazole that potently inhibits human and rat recombinant mPGES-1. | [in vivo]
mPGES-1-IN-2 (compound III) (10-100 mg/kg; ip; single dose) effectively inhibits global prostaglandin production in a mouse model of air sac inflammation induced by 1% λ-Carrageenan (HY-N9470). synthesis and reduce cell migration[1].
| Animal Model: | 1% Carrageenan stimulated mouse air pouch model[1] | | Dosage: | 10, 50, 100 mg/kg | | Administration: | ip; single dose after modeling: use 3 mL of sterile-filtered air was injected sub-cutaneously into the interscapular region of mice; triggered in the pouch 24 h later by the injection of a 1 ml solution of λ-carrageenan (1%) in saline. | | Result: | Had no effect on inflammatory exudate volume but dose-dependently reduced cell migration.
Resulted in a decrease in PGE2 synthesis, it does not affect changes in other prostaglandin levels, but leads to an overall downregulation of prostaglandin synthesis.
|
| [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|