| Identification | Back Directory | [Name]
PIMARIC ACID | [CAS]
127-27-5 | [Synonyms]
NSC 2956
PIMARIC ACID
DextropiMaric Acid
Δ8(14)-PiMaric Acid
8(14),15-PiMaradien-18-oic Acid
PiMara-8(14),15-dien-19-oic Acid
13α-Methyl-13-vinylpodocarp-8(14)-en-15-oic acid
Pimaric Acid (Contains 10-25% Sandaracopimaric Acid)
13-alpha-methyl-13-vinylpodocarp-8(14)-en-15-oic acid
7-trimethyl-,[1theta-(1alpha,4abeta,4balpha,7beta,10aalpha)]-ro-4a
1-phenanthrenecarboxylicacid,7-ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahyd
(1R,4aR,4bS,7S,10aR)-7-Ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-triMethyl-1-phenanthrenecarboxylic Acid
1-Phenanthrenecarboxylic acid, 7-ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-, (1R,4aR,4bS,7S,10aR)- | [Molecular Formula]
C20H30O2 | [MDL Number]
MFCD28369457 | [MOL File]
127-27-5.mol | [Molecular Weight]
302.451 |
| Chemical Properties | Back Directory | [Melting point ]
217-219° | [alpha ]
D18 +74.7° (c = 0.4 in chloroform); D20 +87.3° (in chloroform) | [Boiling point ]
bp18 282° | [density ]
1.0434 (rough estimate) | [refractive index ]
1.4800 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble,Water: soluble | [form ]
Solid | [pka]
4.68±0.60(Predicted) | [color ]
White to off-white | [LogP]
6.731 (est) | [EPA Substance Registry System]
Pimaric acid (127-27-5) |
| Hazard Information | Back Directory | [Uses]
A novel activators of large-conductance Ca2+-activated K+ channel α-subunit. | [Description]
Pimaric acid is a resin acid that has been found in A. cordata and various pines. It reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) in a concentration-dependent manner when used at concentrations ranging from 5 to 20 μM. Pimaric acid (10-20 μM) reduces nuclear expression and binding of the transcription factors NF-κB and AP-1 to the MMP-9 promoter in HASMCs. Pimaric acid also reduces TNF-α-induced HASMC migration to control levels when used at a concentration of 20 μg/ml. | [Definition]
ChEBI: (+)-Pimaric acid is a diterpenoid. |
|
|