| Identification | Back Directory | [Name]
GANGLIOSIDE GD1A DISODIUM SALT | [CAS]
12707-58-3 | [Synonyms]
GD1A
GD1A 2NA
Ganglioside B1
Ganglioside GII
GD1A-GANGLIOSIDE
GANGLIOSIDE GD1A
disialogangloside GD1a
DISIALOGANGLIOSIDE GD1A
DISIALOGANGLIOSIDE GDIA
GD1a-Ganglioside sodium
DISALOGANGLIOSIDE GD1A 2NA
DISIALOGANGLIOSIDE GD1A 2NA
IV3NEUAC, II3NEUAC-GGOSE4CER
Disialoganglioside GD1a ,95%
GANGLIOSIDE GD1A DISODIUM SALT
Ganglioside GD1a (sodium salt)
DISIALOGANGLIOSIDE GD1A, BOVINE
Ganglioside GD1a (Porcine Brain)
GAL(SA)-GALNAC-GAL(SA)-GLC-CERAMIDE
DISIALOGANGLIOSIDE GD1A (NH4+ SALT)
Ganglioside GD1a mixture (sodium salt)
MONOSIALOGANGLIOSIDE GD1A DISODIUM SALT
GANGLIOSIDEGD1ADISODIUMSALT,BOVINEBRAIN
GANGLIOSIDE GD1A DISODIUM SALT USP/EP/BP
disialoganglioside-gd1A from bovine*brain
disialoganglioside G(D1A) from bovine brain
ganglioside gd1a, disialo from bovine brain
DISIALOGANGLIOSIDE-GD1A CELL CULTURE*TES TED
Ganglioside GD1a Mixture (bovine) (ammonium salt)
Ganglioside GD1a Mixture (porcine) (ammonium salt)
GANGLIOSIDEGD1ADISODIUMSALT,BOVINEBRAIN,CELLCULTUREGRADE
Disialoganglioside GD1a from bovine brain,Ganglioside GD1a, disialo from bovine brain | [Molecular Formula]
C84H146N4Na2O39 | [MDL Number]
MFCD00130960 | [MOL File]
12707-58-3.mol | [Molecular Weight]
1882.04 |
| Hazard Information | Back Directory | [Description]
Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver. It can be shed from the surface of tumor cells into the microenvironment where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis. Ganglioside GD1a (20 μM) also increases endothelial cell proliferation. Furthermore, ganglioside GD1a has been shown to act as a functional coreceptor for toll-like receptor 2 (TLR2), enabling the recruitment of TLR2 to lipid rafts when bound by a bacterial toxin. Ganglioside GD1a mixture contains ganglioside GD1a molecular species with C18:1 and C20:1 sphingoid backbones. | [Chemical Properties]
White powder | [Uses]
Ganglioside GD1a Disodium Salt is an agent with a stimulatory effect on phagocytosis and phagosome-lysosome. | [General Description]
Ganglioside GD1a is an anionic brain ganglioside. It is localized in the inner and outer membrane of nuclear envelope of the neuronal cells. GD1a contains a neutral tetrasaccharide core, with one or two sialic acid on the internal galactose. It also has an additional sialic acid on the non-reducing terminal of galactose. | [storage]
Store at -20°C | [References]
[1] PURNA MUKHERJEE. Thematic review series: sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a.[J]. Journal of Lipid Research, 2008: 929-938. DOI: 10.1194/jlr.r800006-jlr200
[2] SHUANG LIANG. Ganglioside GD1a is an essential coreceptor for Toll-like receptor 2 signaling in response to the B subunit of type IIb enterotoxin.[J]. The Journal of Biological Chemistry, 2007, 282 10: 7532-7542. DOI: 10.1074/jbc.m611722200
[3] M IWAMORI. Gangliosides of various rat tissues: distribution of ganglio-N-tetraose-containing gangliosides and tissue-characteristic composition of gangliosides.[J]. Journal of biochemistry, 1984, 95 3: 761-770. DOI: 10.1093/oxfordjournals.jbchem.a134667
[4] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[5] WALKLEY S U. Secondary accumulation of gangliosides in lysosomal storage disorders[J]. Seminars in cell & developmental biology, 2004, 15 4: Pages 433-444. DOI: 10.1016/j.semcdb.2004.03.002 |
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