| Identification | More | [Name]
HS-173 | [CAS]
1276110-06-5 | [Synonyms]
HS-173
ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate
6-[5-[(Phenylsulfonyl)amino]-3-pyridinyl]imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester
6-[5-[(Phenylsulfonyl)amino]-3-pyridinyl]imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester HS-173 | [Molecular Formula]
C21H18N4O4S | [MDL Number]
MFCD28023584 | [MOL File]
1276110-06-5.mol | [Molecular Weight]
422.457 |
| Chemical Properties | Back Directory | [Melting point ]
>193°C (dec.) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly) | [form ]
Solid | [pka]
6.84±0.40(Predicted) | [color ]
Grey to Brown | [InChI]
InChI=1S/C21H18N4O4S/c1-2-29-21(26)19-13-23-20-9-8-15(14-25(19)20)16-10-17(12-22-11-16)24-30(27,28)18-6-4-3-5-7-18/h3-14,24H,2H2,1H3 | [InChIKey]
SEKOTFCHZNXZMM-UHFFFAOYSA-N | [SMILES]
C12=NC=C(C(OCC)=O)N1C=C(C1=CC(NS(C3=CC=CC=C3)(=O)=O)=CN=C1)C=C2 |
| Hazard Information | Back Directory | [Description]
HS-173 is an imidazopyridine analog that acts as a PI3Kα inhibitor with an IC50 value of 0.8 nM.1 It demonstrates antiproliferative activity in T47D, SK-BR-3, and MCF-7 cells with IC50 values of 0.6, 1.5, and 7.8 μM, respectively.1 HS-173 is reported to induce apoptosis by arresting the cell cycle at the G2/M phase and by activating caspases.2,3 It has also been shown to block VEGF-induced angiogenesis both in vitro and in vivo.2 | [Uses]
HS-173 is a potent PI3Kα inhibitor with anticancer activity. | [in vitro]
hs-173 inhibited the pi3k signaling pathway, and showed anti-proliferative effects on cancer cells. also, hs-173 induced cell cycle arrest at the g2/m phase and apoptosis. in addition, hs-173 decreased the expression hif-1a and vegf which play an important role in angiogenesis. this effect was confirmed by the suppression of tube formation and migration assay in vitro [1]. | [in vivo]
hs-173 diminished blood vessel formation in the matrigel plug assay in mice. these results suggest that hs-173 has potent anti-angiogenic activity in vivo [1]. | [target]
PI3Kα | [IC 50]
PI3Kα: 0.8 nM (IC50) | [References]
[1] lee h, jung kh, jeong y, hong s, hong ss. hs-173, a novel phosphatidylinositol 3-kinase (pi3k) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis. cancer lett. 2013 jan 1;328(1):152-9. |
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| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
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