| Identification | More | [Name]
2-FLUORO-5-METHOXYBENZONITRILE | [CAS]
127667-01-0 | [Synonyms]
2-FLUORO-5-METHOXYBENZONITRILE
BUTTPARK 80\01-21
Fluoromethoxybenzonitrile2
2-Fluoro-5-methyloxybenzonitrile
2-Fluoro-5-methoxybenzonitrile98%
6-Fluoro-m-anisonitrile
3-Cyano-4-fluoroanisole | [Molecular Formula]
C8H6FNO | [MDL Number]
MFCD00142921 | [Molecular Weight]
151.14 | [MOL File]
127667-01-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
77-80°C | [Boiling point ]
232.7±25.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [color ]
White to Almost white | [InChI]
1S/C8H6FNO/c1-11-7-2-3-8(9)6(4-7)5-10/h2-4H,1H3 | [InChIKey]
VBZLRHYLNXWZIU-UHFFFAOYSA-N | [SMILES]
Fc1c(cc(cc1)OC)C#N | [CAS DataBase Reference]
127667-01-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
3439 | [WGK Germany ]
3 | [Hazard Note ]
Toxic | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29269090 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 2-fluoro-5-methoxybenzonitrile from the compound (CAS: 796120-91-7) was as follows: 15 g of 2-fluoro-5-methoxybenzaldehyde oxime was dissolved in 150 mL of tetrahydrofuran, followed by the addition of 40 g of trifluoroacetic anhydride. 20 mL of triethylamine was slowly added under stirring. Upon completion of the reaction, the reaction mixture was concentrated to remove the solvent. Water was added to the concentrate and extracted with ethyl acetate. The organic phase was separated, dried with anhydrous sodium sulfate, and then concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography to give 11 g of 2-fluoro-5-methoxybenzonitrile. | [References]
[1] Patent: CN107778264, 2018, A. Location in patent: Paragraph 0029; 0030
[2] Patent: CN107698535, 2018, A. Location in patent: Paragraph 0029; 0030
[3] Patent: CN108129415, 2018, A. Location in patent: Paragraph 0029-0030 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
|