| Identification | Back Directory | [Name]
Hyptadienic acid | [CAS]
128397-09-1 | [Synonyms]
Hyptadienic acid
Benzo[3,4]-18-norandrosta-3,5,15-triene-3(2'H)-carboxylicacid,3',4',5',6'-tetrahydro-3'-hydroxy-15-(hydroxymethyl)-3',4',9,14,17,17-hexamethyl-,(3b,3'a,4b,4'a,8a,9b,10a,13a,14b)- | [Molecular Formula]
C7H10O2 | [MDL Number]
MFCD17214838 | [MOL File]
128397-09-1.mol | [Molecular Weight]
126 |
| Chemical Properties | Back Directory | [Melting point ]
208-210 °C | [Boiling point ]
590.6±50.0 °C(Predicted) | [density ]
1.16±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
4.48±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Hyptadienic acid exhibits moderate cytotoxicity against HepG2 cells.
Hyptadienic acid shows a marked anti-inflammatory effect, it also exhibits strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter. | [Uses]
Hyptadienic acid is a triterpene acid that can be isolated from the leaves of Perilla frutescens. Hyptadienic acid inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice with an ID50 value of 0.13 mg/ear. Hyptadienic acid can be used for the research of inflammation[1]. | [target]
Immunology & Inflammation related | [References]
[1] Banno N, et al. Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. Biosci Biotechnol Biochem. 2004 Jan;68(1):85-90. DOI:10.1271/bbb.68.85 |
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