| Identification | Back Directory | [Name]
[2-(3,4-dimethylphenyl)-3-pyrrol-1-yl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-pyrazin-2-ylmethanone | [CAS]
1286725-49-2 | [Synonyms]
VU0529331
[2-(3,4-dimethylphenyl)-3-pyrrol-1-yl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-pyrazin-2-ylmethanone
Methanone, [2-(3,4-dimethylphenyl)-2,6-dihydro-3-(1H-pyrrol-1-yl)pyrrolo[3,4-c]pyrazol-5(4H)-yl]-2-pyrazinyl- | [Molecular Formula]
C22H20N6O | [MOL File]
1286725-49-2.mol | [Molecular Weight]
384.43 |
| Chemical Properties | Back Directory | [Boiling point ]
631.4±55.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 5 mg/mL (13.01 mM; Need ultrasonic and warming) | [form ]
Solid | [pka]
-0.07±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 μM and 5.2 μM for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel[1]. | [storage]
Store at -20°C | [References]
[1] Kozek KA, et al. Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels. ACS Chem Neurosci. 2018 Sep 13. DOI:10.1021/acschemneuro.8b00287 |
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| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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