| Identification | Back Directory | [Name]
Guanosine-5'-diphosphate disodium salt | [CAS]
7415-69-2 | [Synonyms]
GDP
GDP.Na2
GDP*2Na
GDP, NA2H
5'-GDP-Na2
5'-GDP 3NA
5'-GDP,2Na
Einecs 231-026-2
en pyrophosphate)
Sodium (2R,3R,4R,5R)
5'-GDP-Na
7415-69-2, MFCD00084665, g
-5-(((hydroxy(phosphonooxy)
uanosine 5'-(disodium hydrog
GUANOSINE5-DIPHOSPHATE (GDP)
tetrahydrofuran-3,4-bis(olate)
GDP, 400mM sodium salt solution
-2-(2-amino-6-oxo-1H-purin-9(6H)
Guanosine-5'-diphosphate disodium salt
GUANOSINE-5'-DIPHOSPHATE MONOSODIUM SALT
GUANOSINE-5'-DIPHOSPHORIC ACID, DISODIUM
guanosine 5'-diphosphate disodium salt
GUANOSINE 5'-DIPHOSPHATE DISODIUM SALT 85+%
Guanosine-5'-diphosphate(GDP),diaodium salt
Guanosine 5'-Diphosphate Disodium Salt (~80%)
Guanosine-5''-diphosphoric acid disodium salt
guanosine 5-(disodium hydrogen pyrophosphate)
Guanosine 5'-diphosphate disodium salt >=90% (HPLC)
Guanosine 5'-diphosphate, 400mM sodium salt solution
Guanosine 5-(trihydrogen diphosphate), disodium salt
7415-69-2, MFCD00084665, Guanosine 5'-(disodium hydrogen pyrophosphate)
SodiuM (2R,3R,4R,5R)-2-(2-aMino-6-oxo-1H-purin-9(6H)-yl)-5-(((hydroxy(phosphonooxy)phosphoryl)oxy)Methyl)tetrahydrofuran-3,4-bis(olate) | [EINECS(EC#)]
231-026-2 | [Molecular Formula]
C10H16N5NaO11P2 | [MDL Number]
MFCD00070121 | [MOL File]
7415-69-2.mol | [Molecular Weight]
467.2 |
| Chemical Properties | Back Directory | [Melting point ]
>280°C (dec.) | [storage temp. ]
-20°C | [solubility ]
H2O: 50 mg/mL, clear, colorless
| [form ]
Powder | [color ]
White | [biological source]
Porcine brain
microbial (Corynebacterium sp)
synthetic | [Water Solubility ]
Soluble in water | [Stability:]
Hygroscopic | [InChIKey]
PVMPTWQLNDHIEV-NGPBCCOENA-N | [SMILES]
O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=NC2C(NC(N)=NC1=2)=O)O.[NaH] |&1:1,2,3,15,r| |
| Hazard Information | Back Directory | [General Description]
Guanosine 5′-diphosphate (GDP) is a purine nucleotide and is interconvertible to guanosine by the action of ectonucleotidases and by nucleoside phosphorylase into guanine. GDP is majorly acted upon by 5′‐ectonucleotidases in neuronal cells. | [Biochem/physiol Actions]
Guanosine based nucleosides play a key role in multiple cellular processes and generation growth factors. Elevated levels of guanosine 5′-diphosphate (GDP) is associated with the pathogenesis of neurological disorders. GDP is bound to G protein . G protein coupled receptors (GPCRs) activate G proteins by exchanging the bound GDP to GTP. GDP is potent inhibitor agent of hepcidin- ferroportin complex and may be effective for promoting erythropoiesis and treating anemia of inflammation(AI). | [in vivo]
Guanosine 5'-diphosphate disodium salt (30 mg/kg, i.p., a single dose for 24 h) combined with FeSO4 (2 mg/kg, i.p., a single dose for 24 h) suppresses the iron storage ferritin level, thus preventing Hepcidin (HY-P70400)-induced internalization of FPN with increased iron absorption in normal mice[2].
Guanosine 5'-diphosphate disodium salt (30 mL/kg, i.p., three times a week for two weeks) can improve turpentine-induced inflammatory anemia in mice[1].
| Animal Model: | Male BALB/c mice[2]. | | Dosage: | 30 mL/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Increased hemoglobin levels and serum iron levels in the long-term dosing model.
Decreased Hamp mRNA expression, and spleen iron content was reduced by 46% in the short-term dosing model. |
| [IC 50]
Human Endogenous Metabolite | [storage]
Store at -20°C |
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