| Identification | More | [Name]
2-CHLOROQUINOLINE-3-BORONIC ACID | [CAS]
128676-84-6 | [Synonyms]
2-CHLORO-3-QUINOLYL BORONIC ACID
(2-CHLOROQUINOLIN-3-YL)BORONIC ACID
2-CHLOROQUINOLINE-3-BORONIC ACID
AKOS BRN-0209
2-Chloro-3-quinoline boronic acid | [Molecular Formula]
C9H7BClNO2 | [MDL Number]
MFCD01114675 | [Molecular Weight]
207.42 | [MOL File]
128676-84-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
144-147℃ | [Boiling point ]
426.2±55.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
5.62±0.30(Predicted) | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C9H7BClNO2/c11-9-7(10(13)14)5-6-3-1-2-4-8(6)12-9/h1-5,13-14H | [InChIKey]
JAQXYUOPSOXQCG-UHFFFAOYSA-N | [SMILES]
B(C1=CC2C(N=C1Cl)=CC=CC=2)(O)O | [CAS DataBase Reference]
128676-84-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P280g-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37:Wear suitable gloves . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HS Code ]
2933499090 |
| Hazard Information | Back Directory | [Uses]
2-Chloroquinoline-3-Boronic acid can be converted to 2-chloro-3-hydroxyquinoline in 98% yield by oxidizing with ammonium chloride in aqueous solution with peroxide. Further hydrolysis of 2-chloro-3-hydroxyquinoline yields 3-hydroxy-2-quinolinone. | [Synthesis]
2-Chloroquinoline was lithiated with lithium diisopropylamide in a low-temperature tetrahydrofuran solution, followed by the addition of trimethylborate ester, and finally acidification to obtain 2-Chloroquinoline-3-boronic acid in 85% yield. | [References]
[1] Marsais, F., Godard, A., & Queguiner, G. (1989). Directed ortho-lithiation of chloroquinolines. Application to synthesis of 2,3-disubstituted quinolines. Journal of Heterocyclic Chemistry, 26 6, 1589–1594. https://doi.org/10.1002/jhet.5570260615 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
T&W GROUP
|
| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
|