| Identification | Back Directory | [Name]
ALPHA-CGRP (8-37) (RAT) | [CAS]
129121-73-9 | [Synonyms]
CGRP 8-37 (RAT)
Rat CGRP-(8-37)
PubChem ID: 90479762
RAT CGRP-(8-37)?, >98%
ALPHA-CGRP (8-37) (RAT)
α-CGRP (8-37) (mouse, rat)
a-CGRP (8-37) (Mouse, rat)
Alpha-CGRP (8-37) (mouse, rat)
VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2
CALCITONIN GENE RELATED PEPTIDE (8-37) RAT
Rat CGRP-(8-37)，VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF
Calcitonin Gene Related Peptide (CGRP) (8-37), rat
ALPHA-CALCITONIN GENE-RELATED PEPTIDE (8-37) (RAT)
Rat CGRP-(8-37),VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF, >98%
Alpha-CGRP (8-37) (mouse, rat) trifluoroacetate salt
α-CGRP (8-37) (mouse, rat)|Calcitonin Gene Related Peptide (8-37),rat
α-CGRP (8-37) (mouse, rat),Calcitonin Gene-Related Peptide I (8-37) (mouse, rat), CGRP-I (8-37) (mouse, rat)
VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2
H-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2
α-CGRP (8-37) (canine, Mouse, rat)
Calcitonin Gene-Related Peptide I (8-37) (canine, Mouse, rat), CGRP-I (8-37) (canine, Mouse, rat)
Calcitonin Gene-Related Peptide I (8-37) (canine, Mouse, rat), CGRP-I (8-37) (canine, Mouse, rat), Calcitonin Gene-Related Peptide I (8-37) (Mouse, rat), CGRP-I (8-37) (Mouse, rat)
Biotinyl-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-GlyLeu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-ThrAsn-Val-Gly-Ser-Lys-Ala-Phe-NH2trifluoroacetatesalt(Disulfidebond)
ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7 | [Molecular Formula]
C138H224N42O41 | [MDL Number]
MFCD00671419 | [MOL File]
129121-73-9.mol | [Molecular Weight]
3127.51 |
| Chemical Properties | Back Directory | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C, protect from light | [solubility ]
H2O : 50 mg/mL (15.99 mM; Need ultrasonic) | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
H-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-OH |
| Hazard Information | Back Directory | [Uses]
Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist. | [in vivo]
CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses[1]. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels[2]. | [storage]
-20°C, protect from light | [References]
[1] Bennett AD, et al. Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chroniccentral pain. Pain. 2000 May;86(1-2):163-75. DOI:10.1016/s0304-3959(00)00242-6
[2] Yu LC, et al. The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawalresponses in rats. Brain Res. 1994 Aug 8;653(1-2):223-30. DOI:10.1016/0006-8993(94)90393-x |
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