| Identification | Back Directory | [Name]
tert-butyl(3-hydroxyphenethyl)carbamate | [CAS]
129150-68-1 | [Synonyms]
3-[2-(Boc-amino)ethyl]phenol
tert-butyl(3-hydroxyphenethyl)carbamate
N-(t-butoxycarbonyl)-2-(3-hydroxyphenyl)-ethylamine
Carbamic acid, N-[2-(3-hydroxyphenyl)ethyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C13H19NO3 | [MDL Number]
MFCD24448669 | [MOL File]
129150-68-1.mol | [Molecular Weight]
237.29 |
| Chemical Properties | Back Directory | [Boiling point ]
397.1±25.0 °C(Predicted) | [density ]
1.100±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
9.98±0.10(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
Step B: Synthesis of tert-butyl [2-(3-hydroxyphenyl)ethyl]carbamate; 1 g of 10% Pd/C catalyst was added to a 100 mL ethanol solution containing 13 g (0.039 mol) of tert-butyl [2-(3-benzyloxyphenyl)ethyl]carbamate. The reaction mixture was subjected to hydrogenation at 40 psi hydrogen pressure overnight. Upon completion of the reaction, the catalyst was removed by filtration and washed with ethanol. Subsequently, the solvent was evaporated under reduced pressure to give 9.4 g of tert-butyl 3-hydroxyphenethylcarbamate as a colorless oil in quantitative yield.1H-NMR (CDCl3) δ: 7.22-7.12 (m, 1H); 6.78-6.66 (m, 3H); 4.56 (bs, 1H); 3.42-3.30 (m, 2H); 2.74 (t, 2H); 1.44 (s, 9H). | [References]
[1] Patent: WO2007/71311, 2007, A1. Location in patent: Page/Page column 55-56
[2] Patent: WO2014/95920, 2014, A1. Location in patent: Page/Page column 70
[3] Journal of Organic Chemistry, 1990, vol. 55, # 24, p. 6000 - 6017
[4] Patent: WO2009/68177, 2009, A1. Location in patent: Page/Page column 39
[5] Patent: US2010/210631, 2010, A1. Location in patent: Page/Page column 14 |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|