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156-38-7

156-38-7 Structure

156-38-7 Structure
IdentificationMore
[Name]

4-Hydroxyphenylacetic acid
[CAS]

156-38-7
[Synonyms]

4-HYDROXYPHENYLACETIC ACID
AKOS 236-100
PHPA
P-HYDROPHENYLACETIC ACID
P-HYDROXYPHENYLACETIC ACID
RARECHEM AL BO 0188
(p-hydroxyphenyl)-aceticaci
4-carboxymethylphenol
4-Hydroxybenzeneacetic acid
4-hydroxy-benzeneaceticaci
4-hydroxybenzeneaceticacid
4-hydroxyphenylethanoicacid
Acetic acid, (p-hydroxyphenyl)-
ethanoicacid,4-hydroxyphenyl-
Parahydroxy phenylacetic acid
4-HYDROXYPHENYLACETIC ACID, FOR FLUORESC ENCE
4-HydroxyphenylacetidAcid
Benzeneacetic acid, 4-hydroxy-
2-(4-hydroxyphenyl)acetic acid
4-Hydroxyphenylacetic acid 98%
[EINECS(EC#)]

205-851-3
[Molecular Formula]

C8H8O3
[MDL Number]

MFCD00004347
[Molecular Weight]

152.15
[MOL File]

156-38-7.mol
Chemical PropertiesBack Directory
[Appearance]

white to cream or light tan crystalline powder
[Melting point ]

148-151 °C(lit.)
[mp ]

148-151 °C(lit.)
[Boiling point ]

234.6°C (rough estimate)
[density ]

1.2143 (rough estimate)
[refractive index ]

1.4945 (estimate)
[storage temp. ]

Inert atmosphere,Room Temperature
[solubility ]

50g/l
[form ]

Crystalline Powder
[pka]

4.50±0.10(Predicted)
[color ]

White to cream or light tan
[PH]

2.0-2.4 (30g/l, H2O, 20℃)
[Water Solubility ]

Soluble in dimethyl sulfoxide and methanol. Slightly soluble in water.
[BRN ]

1448766
[InChIKey]

XQXPVVBIMDBYFF-UHFFFAOYSA-N
[CAS DataBase Reference]

156-38-7(CAS DataBase Reference)
[NIST Chemistry Reference]

Benzeneacetic acid, 4-hydroxy-(156-38-7)
[EPA Substance Registry System]

156-38-7(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes .
[WGK Germany ]

3
[RTECS ]

AI2680000
[Hazard Note ]

Irritant
[TSCA ]

Yes
[HS Code ]

29182990
Raw materials And Preparation ProductsBack Directory
【Raw materials】

Phenol-->Glyoxal-->Glyoxylic acid-->4-Aminophenylacetic acid-->BENZYL 2-(4-(BENZYLOXY)PHENYL)ACETATE-->4-Iodophenylacetic acid-->4-Hydroxyphenethyl alcohol-->Methyl 4-chlorophenylacetate-->4-Hydroxybenzyl cyanide-->4-Methoxyphenylacetic acid-->2-hydroxy-1-(4-hydroxyphenyl)ethanone-->3,4-Dihydroxyphenylacetic acid-->4-Hydroxystyrene
【Preparation Products】

2-[3-(2H-Benzotriazol-2-yl)-4-hydroxyphenyl]ethyl methacrylate-->Cefprozil hydrate-->4-Hydroxyphenylacetamide-->4-METHOXYPHENYLACETYL CHLORIDE-->Camostat-->Isobutylparaben-->P-TOLYL-ACETYL CHLORIDE-->Ethyl 4-hydroxyphenylacetate-->Methyl 4-hydroxyphenylacetate-->Bufexamac
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

4-Hydroxyphenylacetic acid(156-38-7).msds
Questions And AnswerBack Directory
[Description]

4-Hydroxyphenylacetic acid is an acetate derivative used in the acylation of phenols and amines1. It is an active component of Chinese herb Aster tataricus which had been widely used in China for the treatment of pulmonary diseases, HBV, and carcinoma. It is an active metabolite of amino acid metabolism. Study has also shown that it can attenuate inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats. In chemical industry, it is an intermediate used to synthesize atenolol and 3, 4-dihydroxyphenylacetic acid.
[Referrence]

  1. Liu, Zhongyang, et al. "4-Hydroxyphenylacetic Acid Attenuated Inflammation and Edema via Suppressing HIF-1α in Seawater Aspiration-Induced Lung Injury in Rats." International Journal of Molecular Sciences 15.7(2014):12861-84.
  2. Ng, T.B.; Liu, F.; Lu, Y.; Cheng, C.H.; Wang, Z. Antioxidant activity of compounds from the medicinal herb Aster tataricus. Comp. Biochem. Physiol. 2003, 136, 109–115. 
  3. Du, L.; Mei, H.F.; Yin, X.; Xing, Y.Q. Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt. Tumour Biol. 2014, 35, 1819–1825.
Hazard InformationBack Directory
[Chemical Properties]

white to cream or light tan crystalline powder
[Uses]

A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.
[Definition]

ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.
[Purification Methods]

Crystallise the acid from water or Et2O/pet ether. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.]
Spectrum DetailBack Directory
[Spectrum Detail]

4-Hydroxyphenylacetic acid(156-38-7)MS
4-Hydroxyphenylacetic acid(156-38-7)1HNMR
4-Hydroxyphenylacetic acid(156-38-7)IR1
4-Hydroxyphenylacetic acid(156-38-7)IR2
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

4-Hydroxyphenylacetic acid, 98%(156-38-7)
[Alfa Aesar]

4-Hydroxyphenylacetic acid, 99%(156-38-7)
[Sigma Aldrich]

156-38-7(sigmaaldrich)
[TCI AMERICA]

4-Hydroxyphenylacetic Acid,>99.0%(GC)(T)(156-38-7)
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