| Identification | Back Directory | [Name]
Y-29794 OXALATE | [CAS]
129184-48-1 | [Synonyms]
Y 29794
Y-29794 OXALATE
[2-(8-Dimethylamino-octylsulfanyl)-6-isopropyl-pyridin-3-yl]-thiophen-2-yl-methanone
Methanone, [2-[[8-(dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienyl-
[2-[[8-(DIMETHYLAMINO)OCTYL]THIO]-6-(1-METHYLETHYL)-3-PYRIDINYL]-2-THIENYLMETHANONE OXALATE | [Molecular Formula]
C23H34N2OS2 | [MDL Number]
MFCD06411588 | [MOL File]
129184-48-1.mol | [Molecular Weight]
418.66 |
| Hazard Information | Back Directory | [Uses]
Y-29794 Oxalate was used in a biological study of nerve growth factor formation enhancement. | [Biological Activity]
Inhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of amyloid β -peptide. Potently inhibits rat brain prolyl endopeptidase (K i = 0.95 nM) in vitro , and prevents amyloid β -peptide deposition in vivo . Orally active and brain penetrant. | [in vivo]
Y-29794 (12.5-50 mg/kg, i.p. daily, 5 times a week for 5 weeks) exhibits antitumor efficacy against triple-negative breast cancer in NOD-SCID mice models, without significant toxicity[1]. | Animal Model: | TNBC xenograft NOD-SCID mice model[1] | | Dosage: | 12.5-50 mg/kg | | Administration: | i.p., daily, 5 times a week for 5 weeks | | Result: | Inhibited tumor growth, maintained body weight. |
| [IC 50]
PREP: 3 nM (IC50) |
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