| Identification | Back Directory | [Name]
UVZBUUTTYHTDRR-QLMKOMRNSA-N | [CAS]
129263-59-8 | [Synonyms]
UVZBUUTTYHTDRR-QLMKOMRNSA-N
5(S),6(R)-Dihydroxy-7(E),9(E),11(E),14(Z)-Eicosatetraenoic acid
7,9,11,14-Eicosatetraenoic acid, 5,6-dihydroxy-, (5S,6R,7E,9E,11E,14Z)-
11-trans-5(S),6(R)-dihydroxy-7(E),9(E),11(E),14(Z)-eicosatetraenoic acid | [Molecular Formula]
C20H32O4 | [MOL File]
129263-59-8.mol | [Molecular Weight]
336.47 |
| Chemical Properties | Back Directory | [Boiling point ]
537.6±50.0 °C(Predicted) | [density ]
1.040±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml | [pka]
4.67±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
(5S,6R)-DiHETEs is the isomer of (5S,6R)-DiHETE (HY-130138A). (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC50 of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists[1]. | [References]
[1] Muller A, et al. Comparative biological activities of the four synthetic (5,6)-dihete isomers. Prostaglandins. 1989 Dec;38(6):635-44. DOI:10.1016/0090-6980(89)90046-4 |
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