| Identification | Back Directory | [Name]
L 669083 | [CAS]
130007-52-2 | [Synonyms]
083
L 669083
3-[1-[(4-Hydroxy-3-iodophenyl)methyl]-3-(4-azidophenylsulfonyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid | [MOL File]
130007-52-2.mol |
| Hazard Information | Back Directory | [Description]
L 669083 is a photoaffinity analogue of two classes of potent leukotriene biosynthesis inhibitors. | [Uses]
L-669083 is a leukotriene biosynthesis inhibitor whose structure is based on a mixture of indole and quinoline. In this study, a potent radioiodinated photoaffinity analog of L-689,037, [125I] L-691,678, was developed and characterized for immunoprecipitation studies showing that the quindole series of leukotriene biosynthesis inhibitors directly interact with FLAP. In addition, the results showed that MK-886, L-674,573, and L-689,037 competed with [125I] L-691,678 and [125I] L-669083 for binding to FLAP in a concentration-dependent manner, indicating that these three leukotriene biosynthesis inhibitors share a binding site on FLAP, further demonstrating that FLAP is a suitable target for structurally diverse leukotriene biosynthesis inhibitors. | [References]
[1] 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. |
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