| Identification | Back Directory | [Name]
Dehydrocorydaline nitrate | [CAS]
13005-09-9 | [Synonyms]
Hydrocortisonenitrate
Dehydrocorydaline nitrate
Dehydrocorydaline nitrate USP/EP/BP
5,6-Dihydro-2,3,9,10-tetramethoxy-13-methyldibenzo[a,g]quinolizinium nitrate | [Molecular Formula]
C22H24NO4.NO3 | [MDL Number]
MFCD03427392 | [MOL File]
13005-09-9.mol | [Molecular Weight]
428.44 |
| Chemical Properties | Back Directory | [Melting point ]
approximate 240℃ (dec.) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Yellow to Dark Yellow | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP[1]. Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities.[2]. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC50?=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain[3]. | [target]
IL Receptor | [storage]
Store at -20°C | [References]
[1] Xu Z, et al. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am J Chin Med. 2012;40(1):177-85. DOI:10.1142/S0192415X12500140
[2] Yoo M, et al. Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation. Mol Med Rep. 2016 Oct;14(4):3029-36. DOI:10.3892/mmr.2016.5653
[3] Nonaka M, et al. Screening of a library of traditional Chinese medicines to identify anti-malarial compounds and extracts. Malar J. 2018 Jun 25;17(1):244. doi: 10.1186/s12936-018-2392-4. DOI:10.1186/s12936-018-2392-4 |
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