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130288-24-3

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130288-24-3 Structure

130288-24-3 Structure
IdentificationBack Directory
[Name]

Duocarmycin SA
[CAS]

130288-24-3
[Synonyms]

CS-1375
Duocarmycin SA
Antibiotic DC 113
Cyclopropacpyrrolo3,2-eindole-6-carboxylic acid, 1,2,4,5,8,8a-hexahydro-4-oxo-2-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (7bR)-
Cyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylicacid,1,2,4,5,8,8a-hexahydro-4-oxo-2-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-,methyl ester, (7bR,8aS)-
[Molecular Formula]

C25H23N3O7
[MDL Number]

MFCD00870411
[MOL File]

130288-24-3.mol
[Molecular Weight]

477.47
Chemical PropertiesBack Directory
[Boiling point ]

787.7±60.0 °C(Predicted)
[density ]

1.53±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

13.12±0.20(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

Duocarmycin SA is an antitumor antibiotic.
[in vivo]

Duocarmycin SA (0.143 mg/kg, i.p., single dose) shows antitumor activity in murine lymphocytic leukemia P388 transplanted in CDF1 mice and shows a significant 30% increase in life span[3].

Animal Model:Murine lymphocytic leukemia P388 transplanted in CDF1 mice [3]
Dosage:0.143 mg/kg
Administration:Intraperitoneal injection (i.p.), single dose
Result:Showed a significant 30% increase in life span.
[IC 50]

Duocarmycins
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