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130308-48-4

130308-48-4 Structure

130308-48-4 Structure
IdentificationBack Directory
[Name]

HOE 140
[CAS]

130308-48-4
[Molecular Formula]

C59H89N19O13S
[MDL Number]

MFCD00213940
[MOL File]

130308-48-4.mol
[Molecular Weight]

1304.52
Chemical PropertiesBack Directory
[density ]

1.60±0.1 g/cm3(Predicted)
[storage temp. ]

−20°C
[pka]

3.60±0.21(Predicted)
[form ]

powder
[color ]

white
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Antagonist (bradykinin).
[Definition]

ChEBI: A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acut attacks of hereditary angioedema in adult patients.
[Brand name]

Metastat (CollaGenex).
[Biological Activity]

A potent and selective bradykinin B2 antagonist. HOE-140 is a useful tool for discrimination of the physiological roles of bradykinin B2 versus B1 receptors. Displays a protective effect in myocardial reperfusion injury.
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