| Identification | Back Directory | [Name]
anhydrotetrodotoxin | [CAS]
13072-89-4 | [Synonyms]
9-anhydro-TTX
anhydrotetrodotoxin
4,9-Anhydrotetrodotoxin
4,9-Dideoxy-4β,9β-epoxytetrodotoxin
(8S)-4,9-Dideoxy-4β,9β-epoxytetrodotoxin
4,9Anhydrotetrodotoxin,4,9 Anhydrotetrodotoxin
(4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol
6,10-Epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol, 2-amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-, (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)- | [Molecular Formula]
C11H15N3O7 | [MDL Number]
MFCD01682463 | [MOL File]
13072-89-4.mol | [Molecular Weight]
301.25 |
| Chemical Properties | Back Directory | [storage temp. ]
-20° | [solubility ]
Soluble in Ethanol (up to 10 mg/ml). | [form ]
A solid or film | [color ]
Colorless | [Water Solubility ]
Soluble to 1 mg/ml in water | [Stability:]
Stable for 2 years from date of purchase as supplied. Protect from exposure to light or moisture. Solutions are not stable. Solutions must be prepared fresh and used within 1 working day. |
| Hazard Information | Back Directory | [Description]
4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 μM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively. | [storage]
Store at -20°C | [References]
1) Rosker?et al. (2007),?The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel; Am.J.Physiol.Cell Physiol.,?293?C783.
2) Denomme?et al.?(2020),??The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6;?Neurosci. Lett.?724?134853 |
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