| Identification | More | [Name]
4-(2-AMINOETHYL)TETRAHYDROPYRAN | [CAS]
65412-03-5 | [Synonyms]
2-(TETRAHYDRO-PYRAN-4-YL)-ETHYLAMINE
4-(2-AMINOETHYL)TETRAHYDROPYRAN
4-(2-Aminoethyl)tetrahydro-2H-pyran
4-(2-Aminoethyl)tetrahydropyrane
4-(2-Aminoethyl)tetrahydro-2H-pyran 97%
4-(2-Aminoethyl)tetrahydropyran ,97% | [EINECS(EC#)]
145-589-6 | [Molecular Formula]
C7H15NO | [MDL Number]
MFCD02179433 | [Molecular Weight]
129.2 | [MOL File]
65412-03-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Irritant/Keep Cold | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless liquid | [Uses]
4-(2-Aminoethyl)tetrahydropyran is a useful pharmaceutical intermediate. | [Synthesis]
General procedure for the synthesis of 4-(2-aminoethyl)tetrahydropyran from 4-cyanomethyltetrahydropyran: (tetrahydro-4-pyranyl)-acetonitrile (75 g, 0.60 mol), Pd/C catalyst (2.5 g), and ethanol (400 mL) were added to a hydrogenation reactor. The air in the reactor was replaced with hydrogen three times, and then the reaction was stirred at 25 °C and 1 MPa hydrogen pressure for 12 hours. After completion of the reaction, the catalyst was removed by filtration, and the filtrate was transferred to a rotary evaporator and distilled under reduced pressure to remove the solvent to give 65.8 g (0.51 mol) of 4-(2-aminoethyl)tetrahydropyran as an oil. | [References]
[1] Patent: CN106083787, 2016, A. Location in patent: Paragraph 0011; 0018; 0019; 0020; 0021; 0022; 0023 |
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