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65412-03-5

65412-03-5 Structure

65412-03-5 Structure
IdentificationMore
[Name]

4-(2-AMINOETHYL)TETRAHYDROPYRAN
[CAS]

65412-03-5
[Synonyms]

2-(TETRAHYDRO-PYRAN-4-YL)-ETHYLAMINE
4-(2-AMINOETHYL)TETRAHYDROPYRAN
4-(2-Aminoethyl)tetrahydro-2H-pyran
4-(2-Aminoethyl)tetrahydropyrane
4-(2-Aminoethyl)tetrahydro-2H-pyran 97%
4-(2-Aminoethyl)tetrahydropyran ,97%
[EINECS(EC#)]

145-589-6
[Molecular Formula]

C7H15NO
[MDL Number]

MFCD02179433
[Molecular Weight]

129.2
[MOL File]

65412-03-5.mol
Chemical PropertiesBack Directory
[Boiling point ]

88-89°C 13mm
[density ]

0.931±0.06 g/cm3(Predicted)
[storage temp. ]

Keep Cold
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

Oil
[pka]

10.34±0.10(Predicted)
[color ]

Clear Colourless
[Detection Methods]

GC,NMR
[CAS DataBase Reference]

65412-03-5(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
[Hazard Note ]

Irritant/Keep Cold
[HS Code ]

29339900
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Ethanol-->Hydrochloric acid-->Ethyl acetate-->Tetrahydrofuran-->Sodium-->Potassium hydroxide-->Acetone-->Hexane-->Lithium Aluminum Hydride-->Sodium cyanide-->Diethyl malonate-->POTASSIUM CYANIDE-->Phosphorus tribromide-->Tetrahydro-2H-pyran-4-carboxylic acid-->2,2'-Dichlorodiethyl ether
Hazard InformationBack Directory
[Chemical Properties]

Clear colorless liquid
[Uses]

4-(2-Aminoethyl)tetrahydropyran is a useful pharmaceutical intermediate.
[Synthesis]

(TETRAHYDRO-PYRAN-4-YL)-ACETONITRILE

850429-50-4

4-(2-AMINOETHYL)TETRAHYDROPYRAN

65412-03-5

General procedure for the synthesis of 4-(2-aminoethyl)tetrahydropyran from 4-cyanomethyltetrahydropyran: (tetrahydro-4-pyranyl)-acetonitrile (75 g, 0.60 mol), Pd/C catalyst (2.5 g), and ethanol (400 mL) were added to a hydrogenation reactor. The air in the reactor was replaced with hydrogen three times, and then the reaction was stirred at 25 °C and 1 MPa hydrogen pressure for 12 hours. After completion of the reaction, the catalyst was removed by filtration, and the filtrate was transferred to a rotary evaporator and distilled under reduced pressure to remove the solvent to give 65.8 g (0.51 mol) of 4-(2-aminoethyl)tetrahydropyran as an oil.

[References]

[1] Patent: CN106083787, 2016, A. Location in patent: Paragraph 0011; 0018; 0019; 0020; 0021; 0022; 0023
Spectrum DetailBack Directory
[Spectrum Detail]

4-(2-AMINOETHYL)TETRAHYDROPYRAN(65412-03-5)1HNMR
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