| Identification | Back Directory | [Name]
JWH 018 5-hydroxyindole metabolite | [CAS]
1307803-43-5 | [Synonyms]
JWH 018 5-hydroxyindole metabolite
(5-hydroxy-1-pentylindol-3-yl)-naphthalen-1-ylmethanone
(5-Hydroxy-1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone
Methanone, (5-hydroxy-1-pentyl-1H-indol-3-yl)-1-naphthalenyl- | [Molecular Formula]
C24H23NO2 | [MOL File]
1307803-43-5.mol | [Molecular Weight]
357.44 |
| Chemical Properties | Back Directory | [Boiling point ]
580.3±30.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml | [form ]
A crystalline solid | [pka]
9.41±0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
JWH 018 5-hydroxyindole metabolite is a major monohydroxylated urinary metabolite of JWH 018, a WIN 55,212-2 derivative that is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor. In urine samples, this metabolite is almost completely glucuronidated. | [Uses]
(5-Hydroxy-1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone is a metabolite in human urine. | [References]
[1] TIM SOBOLEVSKY Grigory R Ilya Prasolov. Detection of JWH-018 metabolites in smoking mixture post-administration urine[J]. Forensic science international, 2010, 200 1: Pages 141-147. DOI: 10.1016/j.forsciint.2010.04.003
[2] KRISHNA C CHIMALAKONDA. Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.[J]. Drug Metabolism and Disposition, 2012, 40 11: 2174-2184. DOI: 10.1124/dmd.112.047530
[3] KRISHNA C CHIMALAKONDA. Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases.[J]. ACS Applied Energy Materials, 2011: 1967-1976. DOI: 10.1124/dmd.111.040709 |
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