| Identification | Back Directory | [Name]
JWH 073 6-hydroxyindole metabolite | [CAS]
1307803-48-0 | [Synonyms]
JWH 073 6-hydroxyindole metabolite
(1-butyl-6-hydroxyindol-3-yl)-naphthalen-1-ylmethanone
Methanone, (1-butyl-6-hydroxy-1H-indol-3-yl)-1-naphthalenyl- | [Molecular Formula]
C23H21NO2 | [MOL File]
1307803-48-0.mol | [Molecular Weight]
343.42 |
| Hazard Information | Back Directory | [Description]
JWH 073 is a mildly selective agonist of the central cannabinoid (CB1) receptor derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding CB1 and the peripheral cannabinoid (CB2) receptor are 8.9 and 38 nM, respectively for a CB1:CB2 ratio of 0.23. JWH 073 is one of several synthetic cannabinoids which have been included in smoking mixtures. JWH 073 6-hydroxyindole metabolite is expected to be a urinary metabolite of JWH 073 based on the metabolism of the closely-related JWH 015 and JWH 018. | [References]
[1] MIE MIE AUNG . Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding[J]. Drug and alcohol dependence, 2000, 60 2: Pages 133-140. DOI: 10.1016/s0376-8716(99)00152-0
[2] QIANG ZHANG. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS[J]. Analytical and Bioanalytical Chemistry, 2006, 386 5: 1345-1355. DOI: 10.1007/s00216-006-0717-6 |
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