| Identification | Back Directory | [Name]
CX-4945 (sodiuM salt) | [CAS]
1309357-15-0 | [Synonyms]
CX-4945 Sodium
CX-4945 (sodiuM salt)
Silmitasertib sodium salt
CX-4945 sodium salt(Silmitasertib)
Silmitasertib sodium salt,CX-4945 sodium salt
CX-4945 sodium salt
(Silmitasertib sodium salt) | [Molecular Formula]
C19H11ClN3NaO2 | [MOL File]
1309357-15-0.mol | [Molecular Weight]
373.77 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
H2O : 16.67 mg/mL (44.84 mM; Need ultrasonic)DMSO : 6.67 mg/mL (17.94 mM; Need ultrasonic) | [form ]
Powder | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Silmitasertib sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. | [in vivo]
Silmitasertib (CX-4945) (25 or 75 mg/kg, p.o.) is well tolerated and demonstrated robust antitumor activity with concomitant reductions of the mechanism-based biomarker phospho-p21 (T145) in murine xenograft models[1]. | [IC 50]
CK2α: 1 nM (IC50); CK2α': 1 nM (IC50) | [References]
[1] Siddiqui-Jain A, et al. CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res. 2010 Dec 15;70(24):10288-98. DOI:10.1158/0008-5472.CAN-10-1893
[2] Kendall JJ, et al. CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin. Oncotarget. 2016 Aug 16;7(33):53191-53203. DOI:10.18632/oncotarget.10668
[3] Buontempo F, et al. Synergistic cytotoxic effects of PS-341 and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB. Oncotarget. 2016 Jan 12;7(2):1323-40. DOI:10.18632/oncotarget.6361
[4] Chon HJ, et al. The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies. Front Pharmacol. 2015 Mar 31;6:70. DOI:10.3389/fphar.2015.00070 |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Musechem
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| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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