| Identification | More | [Name]
tert-Butyl rosuvastatin | [CAS]
355806-00-7 | [Synonyms]
(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester
tert-Butyl (6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoate
tert-butyl rosuvastatin
(+)-(3R, 5S)-7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYL-N-METHANESULFONYLAMINO)PYRIMIDIN-5-YL]-(3, 5)-DIHYDROXY-6(E)-HEPTENOATE
Rosuvastatin intermediate R-3
tert-Butyl(+)-(3R,5S)-7-[4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methanesul
fonylamino)pyrimidin-5-yl]-3,5-Dihydroxy-6(E)-Heptenoate
ZD-8
Tert-butyl-(+)7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidine-5-yl]-(3R,5S)-dihydroxy-(E)-6-Heptena
Tert-butyl-(+)7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidine-5-yl]-(3R,5S)-dihydroxy
(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester
tert-Butyl (6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoate | [EINECS(EC#)]
609-144-4 | [Molecular Formula]
C26H36FN3O6S | [MDL Number]
MFCD08460212 | [Molecular Weight]
537.64 | [MOL File]
355806-00-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
136-138oC | [Boiling point ]
704.2±70.0 °C(Predicted) | [density ]
1.259 | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly, Heated) | [form ]
Solid | [pka]
13.38±0.20(Predicted) | [color ]
White to Off-White | [Optical Rotation]
Consistent with structure | [Stability:]
Hygroscopic | [InChIKey]
IJHZGLLGELSZAF-OKLSWEBGSA-N | [SMILES]
C(OC(C)(C)C)(=O)C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(C)(=O)=O)N=C1C1=CC=C(F)C=C1 | [CAS DataBase Reference]
355806-00-7(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
Rosuvastatin tert-Butyl Ester, is a metabolite of Rosuvastatin (R700500) a selective, competitive HMG-CoA reductase inhibitor. | [Synthesis]
To a 500 ml flask equipped with a nitrogen blower and a mechanical stirrer was added the precursor compound of unsaturated carbonyls (18.60 g), tetrahydrofuran (40.5 ml) and methanol (11.5 ml) and the resulting suspension was stirred at room temperature t |
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