| Identification | Back Directory | [Name]
3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine | [CAS]
131474-72-1 | [Synonyms]
3',5'-TIPS-PAc-rG
3',5'-TIPS-N-PAC-G
N2-Pac-3',5'-TIPDS-Gr
N2-Pac-3',5'-TIPDS-Gr
3',5'-TIPS-N-PAc-Guanosine
N2-Pac-3',5'-O-TIPDSguanosine
N2-Pac-3’,5’-O-TIPDS guanosine
5',3'-tetraisopropyl disiloxane-riboguanosine(N-PAC)
N2-Pac-3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-guanosine
N2-Pac-3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-guanosine
N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine
N2-Phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)guanosine
N-(Phenoxyacetyl)-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]guanosine
3’,5’-O-[1,1,3,3-tetrakis (1-methylethyl)-1,3-disiloxanediyl]-N2-phenoxyacetyl guanosine
Guanosine, N-(2-phenoxyacetyl)-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]- | [Molecular Formula]
C30H45N5O8Si2 | [MOL File]
131474-72-1.mol | [Molecular Weight]
659.88 |
| Hazard Information | Back Directory | [Uses]
N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. | [References]
[1] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100 |
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