| Identification | Back Directory | [Name]
NBTGR | [CAS]
13153-27-0 | [Synonyms]
NBTG
NBTGR
6-(4-nitrobenzylthio)guanosine
S-(4-NITROBENZYL)-6-THIOGUANOSINE
S-(P-NITROBENZYL)-6-THIOGUANOSINE
S-(4-Nitrobenzyl)-6-thioguanosine,99%
2-Amino-6-[(4-nitrobenzyl)thio]-9-β-D-ribofuranosylpurine
2-AMINO-6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE
S-(4-NITROBENZYL)-6-THIOGUANOSINE (NBTG) POTENT ADENOSINE TRAN
NBTG, NBTGR, 2-Amino-6-[(4-nitrobenzyl)thio]-9-β-D-ribofuranosylpurine | [Molecular Formula]
C17H18N6O6S | [MDL Number]
MFCD00005737 | [MOL File]
13153-27-0.mol | [Molecular Weight]
434.43 |
| Chemical Properties | Back Directory | [Appearance]
yellow powder | [Melting point ]
203-205 °C
| [Boiling point ]
858.3±75.0 °C(Predicted) | [density ]
1.3888 (rough estimate) | [refractive index ]
1.7000 (estimate) | [storage temp. ]
0-6°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.07±0.70(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Chemical Properties]
yellow powder | [Uses]
NBTGR (p-Nitrobenzylthioguanosine) is a potent inhibitor of nucleoside transport; inhibits adenosine uptake with a Ki of 70 nM. | [References]
[1] Turnheim K, et al. Inhibition of adenosine uptake in human erythrocytes by adenosine-5'-carboxamides, xylosyladenine, dipyridamole, hexobendine, and p-nitrobenzylthioguanosine. Biochem Pharmacol. 1978;27(18):2191-7. DOI:10.1016/0006-2952(78)90076-x
[2] Parterson A, et al. Nucleoside Transport II Inhibition by p-Nitrobeazylthiogoanosine and Related Compounds. Can. J. Biochem. 49,271-274 (1971) |
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