| Identification | Back Directory | [Name]
SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH | [CAS]
131791-98-5 | [Synonyms]
SUCCINYL-(PRO58,D-GLU65)-HIRUDIN (56-65) (SULFATED)
SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU
SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH
Suc-Phe-Glu-Pro-Ile-Pro-Glu-Glu-Tyr(OSO3H)-Leu-D-Glu-OH
D-Glutamic acid,N-[N-[N-[N-[N-[1-[N-[1-[N-[N-(3-carboxy-1-oxopropyl)-L-phenylalanyl]-L-α-glutamyl]-L-prolyl]-L-isoleucyl]-L-prolyl]-L-α-glutamyl]-L-α-glutamyl]-O-sulfo-L-tyrosyl]-L-leucyl]- | [Molecular Formula]
C64H86N10O25S | [MDL Number]
MFCD00237094 | [MOL File]
131791-98-5.mol | [Molecular Weight]
1427.48 |
| Chemical Properties | Back Directory | [density ]
1.413±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [pka]
-4.17±0.18(Predicted) | [Sequence]
{Suc-Phe}-Glu-Pro-Ile-Pro-Glu-Glu-{Tyr(SO3H)}-Leu-{d-Glu} |
| Hazard Information | Back Directory | [Uses]
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM[1]. | [References]
[1] Dekker RJ, et al. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop. J Mol Biol. 1999 Oct 29;293(3):613-27. DOI:10.1006/jmbi.1999.3178
[2] Payne MH, et al. Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides. J Med Chem. 1991 Mar;34(3):1184-7. DOI:10.1021/jm00107a043 |
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