| Identification | Back Directory | [Name]
5alpha-Hydroxycostic acid | [CAS]
132185-83-2 | [Synonyms]
5α-Hydroxycosticacid
5α-Hydroxycostic acid
5alpha-Hydroxycostic acid
(2R,4aR,8aR)-Decahydro-8a-hydroxy-4a-methyl-alpha,8-bis(methylene)-2-naphthaleneacetic acid
2-Naphthaleneacetic acid, decahydro-8a-hydroxy-4a-methyl-α,8-bis(methylene)-, (2R,4aR,8aR)- | [Molecular Formula]
C15H22O3 | [MDL Number]
MFCD20260447 | [MOL File]
132185-83-2.mol | [Molecular Weight]
250.333 |
| Chemical Properties | Back Directory | [Boiling point ]
406.4±38.0 °C(Predicted) | [density ]
1.12±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
4.42±0.11(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
5α-Hydroxycostic acid, a eudesmane-type sesquiterpene, is isolated from the herb Laggera alata. 5α-Hydroxycostic acid inhibits angiogenesis and suppresses breast cancer cell migration through regulating VEGF/VEGFR2 and Ang2/Tie2 pathways[1]. | [target]
VEGF | Src | AKT | NOS | FAK | PLCγ | ERK | [References]
[1] Liang N, et, al. Two natural eudesmane-type sesquiterpenes from Laggera alata inhibit angiogenesis and suppress breast cancer cell migration through VEGF- and Angiopoietin 2-mediated signaling pathways. Int J Oncol. 2017 Jul;51(1):213-222. DOI:10.3892/ijo.2017.4004 |
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