| Identification | Back Directory | [Name]
Carbamic acid, cyclopropyl-, 1,1-dimethylethyl ester (9CI) | [CAS]
132844-48-5 | [Synonyms]
N-Boc-CycL
N-Boc-cyclopropylamine
tert-Butyl cyclopropylcarbamate
REF DUPL: N-Boc-cyclopropylamine
Cyclopropylamine, N-BOC protected
tert-butyl N-cyclopropylcarbaMate
Cyclopropylamine, N-BOC protected 97%
N-(tert-Butoxycarbonyl)cyclopropylamine
Cyclopropylcarbamic acid tert-butyl ester
N-Cyclopropylcarbamic acid tert-butyl ester
CarbaMic acid, cyclopropyl-, 1,1-diMethylethyl ester
CarbaMic acid, N-cyclopropyl-, 1,1-diMethylethyl ester
Carbamic acid, cyclopropyl-, 1,1-dimethylethyl ester (9CI) | [Molecular Formula]
C8H15NO2 | [MDL Number]
MFCD09701238 | [MOL File]
132844-48-5.mol | [Molecular Weight]
157.21 |
| Chemical Properties | Back Directory | [Melting point ]
62-64° | [Boiling point ]
228.6±7.0 °C(Predicted) | [density ]
1.01±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
12.74±0.20(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
Step 1. Dissolve cyclopropylamine (12.4 g, 252.2 mmol) in dichloromethane (50 mL) at 0°C and cool in an ice water bath. A solution of di-tert-butyl dicarbonate (43.7 g, 200 mmol) in dichloromethane (100 mL) was slowly added dropwise. After the dropwise addition, the reaction mixture was transferred to room temperature and stirred continuously for 18 hours. Upon completion of the reaction, the solvent was removed by vacuum evaporation to afford N-Boc-cyclopropylamine (31 g, 99% yield). | [References]
[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2213 - 2236
[2] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 6, p. 1527 - 1536
[3] Patent: US2007/225280, 2007, A1. Location in patent: Page/Page column 17
[4] Monatshefte fur Chemie, 2017, vol. 148, # 12, p. 2143 - 2153
[5] Organic Letters, 2012, vol. 14, # 17, p. 4458 - 4461 |
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