| Identification | Back Directory | [Name]
ST034307 | [CAS]
133406-29-8 | [Synonyms]
ST034307
ST034307 >=98% (HPLC)
ST034307;ST-034307;ST 034307
6-chloro-2-(trichloromethyl)-4H-chromen-4-one
6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 6-chloro-2-(trichloromethyl)- | [Molecular Formula]
C10H4Cl4O2 | [MDL Number]
MFCD00760793 | [MOL File]
133406-29-8.mol | [Molecular Weight]
297.95 |
| Chemical Properties | Back Directory | [Boiling point ]
329.1±42.0 °C(Predicted) | [density ]
1.674±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml) | [form ]
solid | [color ]
Yellow | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. | [InChI]
1S/C10H4Cl4O2/c11-5-1-2-8-6(3-5)7(15)4-9(16-8)10(12,13)14/h1-4H | [InChIKey]
NTDHYMSVCBGQJF-UHFFFAOYSA-N | [SMILES]
ClC(Cl)(Cl)C1=CC(C2=CC(Cl)=CC=C2O1)=O |
| Hazard Information | Back Directory | [Description]
ST-034307 (133406-29-8) is a?novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. ?It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation.1,3?Displays analgesic properties in a mouse model of inflammatory pain.1?A useful tool for exploring the involvement of AC1 in cellular signalling.2 | [Uses]
ST 034307 is a useful intermediate. | [in vivo]
ST034307 (0.25 μg) causes a significant relief of CFA-induced inflammatory pain in mice. ST034307 exhibits an estimated median effective dose (E50) value for analgesia of 0.28 μg in the mouse pain model[1]. | [storage]
Store at -20°C | [References]
1) Brust?et al.?(2017),?Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties; Sci. Signal,?10?eaah5381
2) Jiang?et al,?(2018),?Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells;. Cell?175?652
3) Watts (2018),?Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain;?Neuropsychopharmacology?43?215 |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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