| Identification | Back Directory | [Name]
PF 1022A | [CAS]
133413-70-4 | [Synonyms]
PF 1022A
PF1022A; PF-1022A
Cyclo(D-2-hydroxypropanoyl-N-methyl-L-leucyl-3-phenyl-D-2-hydroxypropanoyl-N-methyl-L-leucyl-D-2-hydroxypropanoyl-N-methyl-L-leucyl-3-phenyl-D-2-hydroxypropanoyl-N-methyl-L-leucyl)
Cyclo[(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl] | [Molecular Formula]
C52H76N4O12 | [MOL File]
133413-70-4.mol | [Molecular Weight]
949.18 |
| Chemical Properties | Back Directory | [Melting point ]
89-92 °C | [Boiling point ]
1086.6±65.0 °C(Predicted) | [density ]
1.070±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [solubility ]
DMSO: 43 mg/ml | [form ]
A crystalline solid | [pka]
-1.09±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
YJNUXGPXJFAUQJ-XLTXKDBDNA-N |
| Hazard Information | Back Directory | [Uses]
PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against Ascaridia galli in chickens. PF 1022A also can be used for angiostrongyliasis research[1][2][3]. | [Definition]
ChEBI: PF1022A is a cyclooctadepsipeptide. | [storage]
Desiccate at -20°C | [References]
[1] Dornetshuber R, et al. Effects of the anthelmintic drug PF1022A on mammalian tissue and cells. Biochem Pharmacol. 2009 Apr 15;77(8):1437-44. DOI:10.1016/j.bcp.2009.01.005
[2] Sasaki T, et al. A new anthelmintic cyclodepsipeptide, PF1022A. J Antibiot (Tokyo). 1992 May;45(5):692-7. DOI:10.7164/antibiotics.45.692
[3] Nwosu U, et al. Efficacy of the cyclooctadepsipeptide PF1022A against Heligmosomoides bakeri in vitro and in vivo. Parasitology. 2011 Aug;138(9):1193-201. DOI:10.1017/S003118201100076X |
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| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
|