| Identification | Back Directory | [Name]
Fmoc-PEG8-NHS ester | [CAS]
1334170-03-4 | [Synonyms]
Fmoc-NH-PEG8-NHS
Fmoc-PEG8-NHS ester
FmocNH-PEG8-NHS?ester
FmocNH-PEG8-CH2CH2COONHS
Fmoc-N-amido-PEG8-NHS ester
Fmoc-N-amido-dPEG??-NHS ester
Fmoc-N-amido-dPEG (R)8-NHS ester
alpha-(Fmoc-amino)-omega-(succinimidyl propionate) octa(ethylene glycol)
5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid, 29-(2,5-dioxo-1-pyrrolidinyl) 1-(9H-fluoren-9-ylmethyl) ester | [Molecular Formula]
C38H52N2O14 | [MDL Number]
MFCD21363318 | [MOL File]
1334170-03-4.mol | [Molecular Weight]
760.82 |
| Chemical Properties | Back Directory | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Liquid | [pka]
11.60±0.46(Predicted) | [color ]
Colorless to light yellow | [InChIKey]
AMSAHSNOOQLQOU-UHFFFAOYSA-N | [SMILES]
O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O |
| Hazard Information | Back Directory | [Description]
Fmoc-PEG8-NHS ester is a PEG linker containing an Fmoc-protected amine and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | [Uses]
Fmoc-NH-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [reaction suitability]
reaction type: Pegylations
reagent type: cross-linking reagent | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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