| Identification | Back Directory | [Name]
Fmoc-PEG12-NHS ester | [CAS]
2227246-92-4 | [Synonyms]
Fmoc-NH-PEG12-NHS
Fmoc-PEG12-NHS ester
FmocNH-PEG12-NHS?ester
FmocNH-PEG12-CH2CH2COONHS
5,8,11,14,17,20,23,26,29,32,35,38-Dodecaoxa-2-azahentetracontanedioic acid, 41-(2,5-dioxo-1-pyrrolidinyl) 1-(9H-fluoren-9-ylmethyl) ester | [Molecular Formula]
C46H68N2O18 | [MDL Number]
MFCD21363319 | [MOL File]
2227246-92-4.mol | [Molecular Weight]
937.03 |
| Chemical Properties | Back Directory | [storage temp. ]
Storage temp. -20°C | [solubility ]
Soluble in DCM | [form ]
Viscous Liquid | [color ]
Colorless to light yellow | [Stability:]
>=2 years | [InChIKey]
HQKUPHFWWTZASE-UHFFFAOYSA-N | [SMILES]
C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O |
| Hazard Information | Back Directory | [Description]
Fmoc-PEG12-NHS ester is a PEG linker containing an Fmoc-protected amine and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | [Uses]
Fmoc-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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