133978-75-3

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133978-75-3 Structure

Identification	Back Directory
[Name] Folitixorin Calcium
[CAS] 133978-75-3
[Synonyms] Folitixorin Calcium Folic Acid Impurity 13 Calcium Salt
[Molecular Formula] C20H25CaN7O6
[MDL Number] MFCD30747913
[MOL File] 133978-75-3.mol
[Molecular Weight] 499.54

Hazard Information	Back Directory
[Uses] Folitixorin calcium is a cofactor and an analog of leucovorin. Folitixorin calcium is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research[1][2].
[References] [1] Costantini CL, et al. Resection of hepatic metastasis after 5-fluorouracil and cofactor for colon cancer. Hepatogastroenterology. 2009;56(91-92):645-649. PMID:19621672 [2] Carlsson G, et al. 5-fluorouracil (5-FU) and 5,10-methylene tetrahydrofolate (5,10-CH2FH4) as adjuvant therapy in an experimental rodent colon carcinoma model. Anticancer Res. 1997;17(5A):3671-3674. PMID:9413221 [3] Botto LD, et al. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol. 2000;151(9):862-877. DOI:10.1093/oxfordjournals.aje.a010290

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