| Identification | Back Directory | [Name]
Adenosine, 2-chloro-N-methyl- | [CAS]
13406-50-3 | [Synonyms]
Regadenoson Impurity 43
2-Chloro-N6-methyladenosine
Adenosine, 2-chloro-N-methyl-
(2R,3R,4S,5R)-2-(2-Chloro-6-(methylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | [Molecular Formula]
C11H14ClN5O4 | [MOL File]
13406-50-3.mol | [Molecular Weight]
315.71 |
| Hazard Information | Back Directory | [Uses]
2-Chloro-N6-methyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. | [References]
[1] Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. DOI:10.1016/j.drudis.2021.02.020
[2] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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