| Identification | Back Directory | [Name]
N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-L-alanine | [CAS]
1342211-31-7 | [Synonyms]
MC-Val-Ala-OH
(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl)-L-valyl-L-alanine
N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-L-alanine
L-Alanine, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl- | [Molecular Formula]
C18H27N3O6 | [MOL File]
1342211-31-7.mol | [Molecular Weight]
381.42 |
| Chemical Properties | Back Directory | [Boiling point ]
695.4±50.0 °C(Predicted) | [density ]
1.232±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.44±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MC-Val-Ala-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [Biological Activity]
MC-Val-Ala-OH is a cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs). | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
| [IC 50]
Protease Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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Nextpeptide Inc
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