| Identification | Back Directory | [Name]
2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL | [CAS]
86520-52-7 | [Synonyms]
Azido-PEG3
N3-PEG3-OH
Azido-PEG3-alcohol
8-Azido-3,6-dioxaoctanol
1-Azido-8-hydroxy-3,6-dioxaoctane
8-Azido-3,6-dioxaoctanol solution
2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL
2-[2-(2-azidoethoxy)ethoxy]ethan-1-ol
2-[2-(2-Azidoethoxy)ethoxy]ethanol solution | [Molecular Formula]
C6H13N3O3 | [MDL Number]
MFCD09753542 | [MOL File]
86520-52-7.mol | [Molecular Weight]
175.186 |
| Chemical Properties | Back Directory | [Appearance]
Yellowish Liquid | [Fp ]
-33℃ | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Oil | [color ]
Colourless to Light Yellow | [BRN ]
4418543 | [InChI]
InChI=1S/C6H13N3O3/c7-9-8-1-3-11-5-6-12-4-2-10/h10H,1-6H2 | [InChIKey]
PMNIHDBMMDOUPD-UHFFFAOYSA-N | [SMILES]
C(O)COCCOCCN=[N+]=[N-] |
| Hazard Information | Back Directory | [Chemical Properties]
Yellowish Liquid | [Description]
Azido-PEG3-alcohol is a click chemistry PEG linker containing an azide group and a terminal hydroxyl group. The azide group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. | [Uses]
Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Azido-PEG3-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [reaction suitability]
reaction type: click chemistry
reagent type: linker | [IC 50]
PEGs | [References]
[1] Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. DOI:10.1016/j.bmc.2019.115228 |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS02,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H225-H315 | [Precautionary statements ]
P210 | [Hazard Codes ]
F,Xi | [Risk Statements ]
11-38 | [Safety Statements ]
16 | [RIDADR ]
UN 2398 3 / PGII | [WGK Germany ]
3 | [HS Code ]
2929900090 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Flam. Liq. 2
Skin Irrit. 2 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
T&W GROUP
|
| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
| Company Name: |
Acesys Pharmatech
|
| Telephone: |
18860950986 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15849/0_EN.htm |
|