| Identification | Back Directory | [Name]
N3-PEG8-CH2COOH | [CAS]
1343472-07-0 | [Synonyms]
N3-PEG8-CH2COOH
N3-PEG8-CH2CO2H
AZIDE-PEG8-CH2COOH
Azido-PEG8-CH2CO2H | [Molecular Formula]
C18H35N3O10 | [MDL Number]
MFCD30729542 | [MOL File]
1343472-07-0.mol | [Molecular Weight]
453.49 |
| Hazard Information | Back Directory | [Description]
Azido-PEG8-CH2CO2H is a aqueous soluble PEG linker. The hydrophilic PEG spacer increases solubility in aqueous media. Azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
N3-PEG8-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. N3-PEG8-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] Steinmetz NF, et al. Intravital imaging of human prostate cancer using viral nanoparticles targeted to gastrin-releasing Peptide receptors. Small. 2011 Jun 20;7(12):1664-72. DOI:10.1002/smll.201000435 |
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